In recent years we have seen a rapid increase in heart disease caused to a large extent by excessive mental stress. ”Interpersonal relations are stressing me out, I'm depressed, and can't concentrate on my work. Recently I have been inundated with work, and tired all the time….” No doubt we have all felt these symptoms of stress from time to time. Meanwhile, cognitive decline associated with aging causes a host of problems. To address these neurological and heart-related issues, world-class scientists and researchers have come together and are pursing cutting-edge research and development. Yoshinori Yamakawa, manager in charge of the whole program, recently shared his thoughts about the objectives and nature of the research, and how it might be utilized in the future.